Mouse Low density lipoprotein receptor adapter protein 1 (LDLRAP1) ELISA Kit

LDLRAP1 is a protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes.Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits.

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SPECIFICATIONS

Catalog Number

KTE71191

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

100017

Accession

Q8C142

Additional Info

Mouse Low density lipoprotein receptor adapter protein 1 (LDLRAP1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse LDLRAP1. No significant cross-reactivity or interference between Mouse LDLRAP1 and analogues was observed.