Mouse LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) ELISA Kit

LIMS1 is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.While ILK depletion reduced AKT phosphorylation on ser473, PINCH1 depletion reduced AKT phosphorylation on both ser473 and thr308. PINCH1 also regulated ILK protein levels.

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SPECIFICATIONS

Catalog Number

KTE71175

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

110829

Accession

Q99JW4

Additional Info

Mouse LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse LIMS1. No significant cross-reactivity or interference between Mouse LIMS1 and analogues was observed.