Mouse Leukemia-associated protein 7 (DLEU7) ELISA Kit

Deletion of chromosome 13q14 is the most frequent genetic aberration in B-cell chronic lymphocytic leukemia (CLL), found in more than 50% of cases, indicating that this region contains a gene(s) involved in the development of CLL.DLEU7, located adjacent to the consensus deleted region, and overlapping the 3' end of DLEU1 tail to tail. Human DLEU7 encodes a putative 221 amino acid protein, with significant conservation in rodents. Mutational and expression analysis in primary CLL samples failed to demonstrate any specific mutations in DLEU7, but no DLEU7 expression could be detected in CLL cells. Methylation of a CpG island in the promoter region of DLEU7 was further analyzed as a possible mechanism for the absence of DLEU7 expression, and the promoter was found to be methylated in the majority of the CLL samples investigated.

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SPECIFICATIONS

Catalog Number

KTE71259

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

239133

Accession

Q8CHZ8

Additional Info

Mouse Leukemia-associated protein 7 (DLEU7) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse DLEU7. No significant cross-reactivity or interference between Mouse DLEU7 and analogues was observed.