Mouse Krueppel-like factor 1 (KLF1) ELISA Kit

Erythroid KrГјppel-like Factor (EKLF) is a transcription factor that is necessary for the proper maturation of erythroid (red blood) cells. The molecule has two domains; the transactivation domain and the chromatin-remodeling domain. The carboxyl (C) terminal is composed of three C2H2 zinc fingers that binds to DNA, and the amino (N) terminus is proline rich and acidic. The gene for EKLF is on the human chromosome 19 and on mouse chromosome 8.\nEKLF deficient (knockout) mouse embryos exhibit a lethal anemic phenotype, fail to promote the transcription of adult ? globin, and die by embryonic day 14. On the other hand, over-expression of EKLF results in a reduction of the number of circulating platelets and hastens the onset of ? globin gene.

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SPECIFICATIONS

Catalog Number

KTE71208

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Accession

P46099

Additional Info

Mouse Krueppel-like factor 1 (KLF1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse KLF1. No significant cross-reactivity or interference between Mouse KLF1 and analogues was observed.