Mouse DNA polymerase beta (POLB) ELISA Kit

DNA polymerase beta maintains genome integrity by participating in base excision repair. Over expression of POLB mRNA has been correlated with a number of cancer types whereas deficiencies in POLB results in hypersensitivity to alkylating agents, induced apoptosis and chromosomal breaking therefore it is essential that POLB expression is tightly regulated.\nPOLB gene is upregulated by CREB1 transcription factor binding to the cAMP response element(CRE) present in the promoter of the POLB gene in response to exposure to alkylating agents. POLB gene expression is also regulated at the post transcriptional level as the 3вЂ™UTR of the POLB mRNA has been shown to contain three stem-loop structures that influence gene expression.

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SPECIFICATIONS

Catalog Number

KTE70715

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

18970

Accession

Q8K409

Additional Info

Mouse DNA polymerase beta (POLB) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse POLB. No significant cross-reactivity or interference between Mouse POLB and analogues was observed.