Mouse Dickkopf-related protein 4 (DKK4) ELISA Kit

All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis detected no expression of DKK4, but RT-PCR analysis detected DKK4 expression in cerebellum, T-cell, esophagus, and lung cDNA libraries. Western blot analysis showed that DKK4 is secreted as 40-, 30- to 32-, and 15- to 17-kD proteins; these proteins were not significantly affected by N-glycanase treatment. N-terminal sequence analysis of the different forms suggested that DKK4 is proteolytically processed, possibly by intracellular furin-type proteases. Functional analysis determined that DKK4 blocks Xenopus Wnt8, Wnt3a, and Wnt2b, but not Dsh or Fz8, induction of a secondary axis in frog embryos, indicating that DKKs antagonize WNT function upstream of WNT receptors.

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SPECIFICATIONS

Catalog Number

KTE71264

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

234130

Accession

Q8VEJ3

Additional Info

Mouse Dickkopf-related protein 4 (DKK4) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse DKK4. No significant cross-reactivity or interference between Mouse DKK4 and analogues was observed.