Mouse Dickkopf-related protein 2 (DKK2) ELISA Kit

Dickkopf-related protein 2 is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).Northern blot analysis revealed expression of 4.0- and 4.5-kb DKK2 transcripts in heart, brain, skeletal muscle, and lung. Western blot analysis showed that DKK2 is secreted as a 15- to 17-kD protein. Functional analysis determined that DKK2 does not block Xenopus Wnt8 induction of a secondary axis in frog embryos.

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SPECIFICATIONS

Catalog Number

KTE71266

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

56811

Accession

Q9QYZ8

Additional Info

Mouse Dickkopf-related protein 2 (DKK2) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse DKK2. No significant cross-reactivity or interference between Mouse DKK2 and analogues was observed.