Mouse Diamine oxidase (DAO) ELISA Kit

On the basis of its primary structure, the amiloride-binding protein (EC 1.4.3.6) is 713 amino acids long, with a 19-amino acid signal peptide. Expressed in cultured cells, the mRNA yields a glycoprotein that binds amiloride and amiloride analogs with affinities similar to the amiloride receptor associated with the apical Na+ channel in pig kidney membranes and is immunoprecipitated with monoclonal antibodies raised against pig kidney amiloride-binding protein. Barbry et al. (1990) pointed out that amiloride-sensitive Na+ channels are also present in airway epithelia, where they play an important role in fluid secretion. Amiloride inhibits the excessive absorption of Na+ and liquid that takes place in airway epithelia of patients with cystic fibrosis, and amiloride aerosol therapy has been tried for the treatment of lung disease in CF.

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SPECIFICATIONS

Catalog Number

KTE70533

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Accession

Q8JZQ5

Additional Info

Mouse Diamine oxidase (DAO) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse ABP1. No significant cross-reactivity or interference between Mouse ABP1 and analogues was observed.