Mouse Cyclophilin A (CyPA) ELISA Kit

Cyclophilin A, also called Peptidyl-prolyl Isomerase A, PPIA, CYPA, and CYPH, was originally characterized for its ability to catalyze the transition between cis- and trans- proline residues critical for proper folding of proteins. Cyclophilin is also incorporated into many viruses, including HIV-1, where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin, making it a useful inhibitor for studying calcineurin activity.

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SPECIFICATIONS

Catalog Number

KTE70707

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

268373

Accession

P17742

Additional Info

Mouse Cyclophilin A (CyPA) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PPIA. No significant cross-reactivity or interference between Mouse PPIA and analogues was observed.