Mouse CAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) ELISA Kit

Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. PRKAR1b is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.\nBAD is required to assemble the complex, the lack of which results in diminished mitochondria-based glucokinase activity and blunted mitochondrial respiration in response to glucose. Glucose deprivation results in dephosphorylation of BAD, and BAD-dependent cell death.

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SPECIFICATIONS

Catalog Number

KTE70671

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

19085

Accession

P12849

Additional Info

Mouse CAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PRKAR1B. No significant cross-reactivity or interference between Mouse PRKAR1B and analogues was observed.