Mouse Calcipressin-1 (RCAN1) ELISA Kit

RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. The predicted 171-amino acid protein contains 2 proline-rich regions, a putative DNA-binding domain, and an acidic region. Northern blot analysis revealed that the 2.2-kb DSCR1 transcript is expressed at the highest levels in fetal brain and adult heart and at lower levels in various other tissues. An additional 2-kb mRNA was detected in fetal and adult liver.

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SPECIFICATIONS

Catalog Number

KTE70516

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

54720

Accession

Q9JHG6

Additional Info

Mouse Calcipressin-1 (RCAN1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse RCAN1. No significant cross-reactivity or interference between Mouse RCAN1 and analogues was observed.