Mouse Brain-specific serine protease 4 (PRSS22) ELISA Kit

The deduced 317-amino acid protein contains an N-terminal hydrophobic leader peptide, followed by a propeptide sequence and the serine protease domain, which has the catalytic triad of histidine, aspartic acid, and serine. PRSS22 also has 2 cysteines that form a disulfide bond linking the propeptide and the catalytic domain following proteolytic activation, and it has an N-glycosylation site. PRSS22 lacks a number of residues required by other tryptases to form tetramers. RNA dot blot analysis detected abundant PRSS22 expression in adult esophagus and trachea, with lower levels in adult placenta, pancreas, prostate, and thyroid, and in fetal kidney and lung. There was little to no expression in other tissues examined. Enzymatically active PRSS22 was secreted from a human epithelial cell line and from transfected COS-7 cells.

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SPECIFICATIONS

Catalog Number

KTE70638

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

70835

Accession

Q9ER10

Additional Info

Mouse Brain-specific serine protease 4 (PRSS22) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PRSS22. No significant cross-reactivity or interference between Mouse PRSS22 and analogues was observed.