Mouse ATP-binding cassette sub-family A member 1 (ABCA1) ELISA Kit

ABCA1 was discovered as the mutation causing Tangier's Disease by several groups in 1998. Gerd Schmitz's group in Germany and Michael Hayden's group in British Columbia were using standard genetics techniques and DNA from family pedigrees to locate the mutation.\nRichard Lawn's group at CV Therapeutics in Palo Alto, CA used cDNA microarrays, which were relatively new at the time, to assess gene expression profiles from cell lines created from normal and effected individuals. They showed cell lines from patients with Tangier's disease showed differential regulation of the ABCA1 gene. Subsequent sequencing of the gene identified the mutations. This group received an award from the American Heart Association for their discovery.

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SPECIFICATIONS

Catalog Number

KTE70524

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

11303

Accession

P41233

Additional Info

Mouse ATP-binding cassette sub-family A member 1 (ABCA1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse ABCA1. No significant cross-reactivity or interference between Mouse ABCA1 and analogues was observed.