Mouse Advanced glycosylation end product-specific receptor (AGER) ELISA Kit

RAGE, the receptor for advanced glycation endproducts is a 35kD transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al.. Its name comes from its ability to bind advanced glycation endproducts (AGE), a heterogeneous group of non-enzymatically altered proteins. Besides AGEs, RAGE is also able to bind other ligands and is thus often referred to as a pattern recognition receptor.The interaction between RAGE and its ligands is thought to result in pro-inflammatory gene activation. Due to an enhanced level of RAGE ligands in diabetes or other chronic disorders, this receptor is hypothesised to have a causative effect in a range of inflammatory diseases such as diabetic complications, Alzheimer's disease and even some tumors.

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SPECIFICATIONS

Catalog Number

KTE70568

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

11596

Accession

Q62151

Additional Info

Mouse Advanced glycosylation end product-specific receptor (AGER) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse AGER. No significant cross-reactivity or interference between Mouse AGER and analogues was observed.