Mouse Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) ELISA Kit

ACAT1 is a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.The 427-amino acid precursor had a molecular mass of 45.2 kD. The sequence included a 33-residue leader peptide and a 394-amino acid subunit of the mature enzyme, which had a molecular mass of 41.4 kD. In all 4 cell lines, the T2 mRNA had the same 1.7-kb transcript as that of the control; however, content was reduced in 2 cell lines and normal in the other 2. Human T2 is a homotetramer of 41-kD subunits.

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SPECIFICATIONS

Catalog Number

KTE70536

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

110446

Accession

Q8QZT1

Additional Info

Mouse Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse ACAT1. No significant cross-reactivity or interference between Mouse ACAT1 and analogues was observed.