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JNK1/2/3 Polyclonal Antibody

Cat no: ABP51664

JNK1/2/3 Polyclonal Antibody

Mitogen-activated protein kinase 8 encoded by MAPK8 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

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SPECIFICATIONS

Catalog Number

ABP51664

Size

30micro l, 100micro l, 200micro l

Applications

ELISA, IF, IHC-F, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Gene Id

5599/5601/5602

Isotype

Rabbit IgG

Accession

P45983/P45984/P53779

Clonality

Polyclonal

Concentration

1 mg/ml

SUPPLIER INFO

Abbkine Scientific Co.Ltd.

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