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IDE Monoclonal Antibody

Cat no: ABM40083

IDE Monoclonal Antibody

IDE encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of insulin degrading enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in IDE have not been shown to be causitive for these diseases. Insulin degrading enzyme localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

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SPECIFICATIONS

Catalog Number

ABM40083

Size

30micro l, 100micro l, 200micro l

Applications

IF, IHC-F, WB

Hosts

Mouse

Reactivities

Hum

Gene Id

3416

Isotype

Mouse IgG1

Accession

P14735

Clonality

Monoclonal

Concentration

1 mg/ml

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