Human Thymosin beta-4, Y-chromosomal (TMSB4Y) ELISA Kit

Lahn and Page (1997) isolated testis cDNAs encoding TB4Y, a Y-linked TB4X homolog. They identified TB4Y as 1 of 5 NRY genes that were expressed in many tissues and have homologs on the X chromosome that escape X inactivation.\nThe antigen, an 11-mer peptide (EVLLRPGLHFR), was encoded by a polymorphic region 405 bp upstream of the initiation codon of TMSB4Y. CTL precursor frequency analysis showed that approximately 25% of the total donor CTL responses in the patient 50 days after transplant were directed at this epitope, and the precursor was detectable almost 2 years after transplant. RT-PCR analysis detected wide expression of TMSB4Y mRNA in normal tissues, including hematopoietic cells, and TMSB4Y was also expressed in some leukemic cells.

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SPECIFICATIONS

Catalog Number

KTE62320

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

9087

Accession

O14604

Additional Info

Human Thymosin beta-4, Y-chromosomal (TMSB4Y) ELISA Kit has high sensitivity and excellent specificity for detection of Human TMSB4Y. No significant cross-reactivity or interference between Human TMSB4Y and analogues was observed.