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Human Thrombin activatable fibrinolysis inhibitor (TAFI) ELISA Kit

Cat no: KTE62275

Human Thrombin activatable fibrinolysis inhibitor (TAFI) ELISA Kit

TAFI, Thrombin Activatable Fibrinolytic Inhibitor, (also known as carboxypeptidase U and plasma carboxypeptidase B) is a 60,000 D molecular ratio glycoprotein (proenzyme form) present in rabbit plasma1 that modulates fibrinolysis in vivo. This proenzyme is converted to a 35,000 D molecular ratio active form, TAFIa, following proteolytic cleavage by the thrombin/ thrombomodulin complex. TAFIa possesses carboxypeptidase activity with a preference for cleaving lysine and arginine residues from the c-terminus of proteins. Modulation of fibrinolysis occurs when TAFIa cleaves C-terminal arginine and lysine residues of partially degraded fibrin.2,4,5 The removal of the c-terminus arginine and lysine residues from fibrin inhibits the continued degradation of fibrin by tPA activated plasmin.3

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SPECIFICATIONS

Catalog Number

KTE62275

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

1361

Accession

Q96IY4

Additional Info

Human Thrombin activatable fibrinolysis inhibitor (TAFI) ELISA Kit has high sensitivity and excellent specificity for detection of Human CPB2. No significant cross-reactivity or interference between Human CPB2 and analogues was observed.

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