Human Soluble cluster of differentiation 14 (sCD14) ELISA Kit

CD14 exists in two forms. It is either anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 appears either after shedding of mCD14 (48 KDa) or is directly secreted from intracellular vesicles (56 KDa).CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins. CD14 was the first described pattern recognition receptor.CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can only bind LPS in the presence of lipopolysaccharide-binding protein (LBP). Although LPS is considered its main ligand CD14 also recognizes other pathogen associated molecular patterns.

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SPECIFICATIONS

Catalog Number

KTE62286

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

929

Accession

P08571

Additional Info

Human Soluble cluster of differentiation 14 (sCD14) ELISA Kit has high sensitivity and excellent specificity for detection of Human CD14. No significant cross-reactivity or interference between Human CD14 and analogues was observed.