Human Sister chromatid cohesion protein DCC1 (DSCC1) ELISA Kit

RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. The predicted 171-amino acid protein contains 2 proline-rich regions, a putative DNA-binding domain, and an acidic region. Northern blot analysis revealed that the 2.2-kb DSCR1 transcript is expressed at the highest levels in fetal brain and adult heart and at lower levels in various other tissues. An additional 2-kb mRNA was detected in fetal and adult liver.

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SPECIFICATIONS

Catalog Number

KTE61977

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

79075

Accession

Q9BVC3

Additional Info

Human Sister chromatid cohesion protein DCC1 (DSCC1) ELISA Kit has high sensitivity and excellent specificity for detection of Human DSCC1. No significant cross-reactivity or interference between Human DSCC1 and analogues was observed.