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Human Plakophilin-1 (PKP1) ELISA Kit

Cat no: KTE62209

Human Plakophilin-1 (PKP1) ELISA Kit

Plakophilin-1 is a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome.Compared with those in controls, desmosomes in PKP1- patients were reduced dramatically both in size (49%) and frequency (61%) in the lower suprabasal layers (P less than 0.01). In the lower suprabasal compartment of the heterozygous carrier, corresponding reductions were 37% and 20%, respectively (P less than 0.01).

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SPECIFICATIONS

Catalog Number

KTE62209

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

5317

Accession

Q13835

Additional Info

Human Plakophilin-1 (PKP1) ELISA Kit has high sensitivity and excellent specificity for detection of Human PKP1. No significant cross-reactivity or interference between Human PKP1 and analogues was observed.

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