Human Neuronal migration protein doublecortin (DCX) ELISA Kit

DCX encodes a member of the doublecortin family. The protein encoded by DCX is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in DCX cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for DCX.

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SPECIFICATIONS

Catalog Number

KTE62125

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

1641

Accession

O43602

Additional Info

Human Neuronal migration protein doublecortin (DCX) ELISA Kit has high sensitivity and excellent specificity for detection of Human DCX. No significant cross-reactivity or interference between Human DCX and analogues was observed.