Human Myotonin-protein kinase (DMPK) ELISA Kit

Myotonic dystrophy protein kinase is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

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SPECIFICATIONS

Catalog Number

KTE62013

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

1760

Accession

Q09013

Additional Info

Human Myotonin-protein kinase (DMPK) ELISA Kit has high sensitivity and excellent specificity for detection of Human DMPK. No significant cross-reactivity or interference between Human DMPK and analogues was observed.