Human Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) ELISA Kit

MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1. The predicted 211-amino acid MAD2B protein shares 24% and 26% sequence identity with yeast Mad2 and human MAD2L1, respectively, in the conserved regions. RT-PCR analysis revealed that both human MAD2 homologs were expressed at similar high levels in a panel of cell lines. Further binding analyses determined that the interaction of MAD2L2 with ADAM9 is mediated through a proline-rich SH3-ligand domain of ADAM9. Northern blot analysis detected 1.35-kb MAD2L3 transcripts in all tissues tested, with highest expression in testis.

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SPECIFICATIONS

Catalog Number

KTE61757

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

10459

Accession

Q9UI95

Additional Info

Human Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) ELISA Kit has high sensitivity and excellent specificity for detection of Human MAD2L2. No significant cross-reactivity or interference between Human MAD2L2 and analogues was observed.