Human Mitogen-activated protein kinase kinase kinase 6 (MAP3K6) ELISA Kit

MAP3K6 is a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.\nMAP3K6 and MAP3K5 share 45% amino acid sequence identity; their catalytic domains share 82% identity. The authors confirmed the interaction of MAP3K6 with MAP3K5 in vivo using coimmunoprecipitation. Recombinant MAP3K6 weakly activated the JNK but not the ERK or p38 kinase pathways.

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SPECIFICATIONS

Catalog Number

KTE62235

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

9064

Accession

O95382

Additional Info

Human Mitogen-activated protein kinase kinase kinase 6 (MAP3K6) ELISA Kit has high sensitivity and excellent specificity for detection of Human MAP3K6. No significant cross-reactivity or interference between Human MAP3K6 and analogues was observed.