Human Mitochondrial antiviral-signaling protein (MAVS) ELISA Kit

These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB), which activate NFKB , or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.

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SPECIFICATIONS

Catalog Number

KTE61707

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

57506

Accession

Q7Z434

Additional Info

Human Mitochondrial antiviral-signaling protein (MAVS) ELISA Kit has high sensitivity and excellent specificity for detection of Human MAVS. No significant cross-reactivity or interference between Human MAVS and analogues was observed.