Human Metastasis-associated in colon cancer protein 1 (MACC1) ELISA Kit

MACC1 is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (HGFR, or MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival.The deduced 852-amino acid has an SH3 domain, a proline-rich motif for binding SH3 domain-containing proteins, additional binding motifs for SH2 and SH3 domain-containing proteins, EPS15 homology domains, clathrin and retinoblastoma protein (RB1) interaction domains, and putative tyrosine phosphorylation sites. It shares about 44% identity with SH3BP4, and putative orthologs were identified in chicken, mouse, rat, dog, and chimp.

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SPECIFICATIONS

Catalog Number

KTE61759

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

346389

Accession

Q6ZN28

Additional Info

Human Metastasis-associated in colon cancer protein 1 (MACC1) ELISA Kit has high sensitivity and excellent specificity for detection of Human MACC1. No significant cross-reactivity or interference between Human MACC1 and analogues was observed.