Human Mediator of RNA polymerase II transcription subunit 12 (MED12) ELISA Kit

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by MED12, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in MED12 cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.

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SPECIFICATIONS

Catalog Number

KTE61671

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

9968

Accession

Q93074

Additional Info

Human Mediator of RNA polymerase II transcription subunit 12 (MED12) ELISA Kit has high sensitivity and excellent specificity for detection of Human MED12. No significant cross-reactivity or interference between Human MED12 and analogues was observed.