Human Mediator of RNA polymerase II transcription subunit 1 (MED1) ELISA Kit

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. Mediator of RNA polymerase II transcription subunit 1 encoded by MED1 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. Mediator of RNA polymerase II transcription subunit 1 is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. Mediator of RNA polymerase II transcription subunit 1 is known to have the ability to self-oligomerize.В

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SPECIFICATIONS

Catalog Number

KTE61673

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

5469

Accession

Q15648

Additional Info

Human Mediator of RNA polymerase II transcription subunit 1 (MED1) ELISA Kit has high sensitivity and excellent specificity for detection of Human MED1. No significant cross-reactivity or interference between Human MED1 and analogues was observed.