Human Matrix metalloproteinase 2/Gelatinase A (MMP-2) ELISA Kit

MMP2 is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by MMP2 is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in MMP2 have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Prices direct from Abbkine Scientific Co.Ltd.

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Catalog Number

KTE62230

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

4313

Accession

P08253

Additional Info

Human Matrix metalloproteinase 2/Gelatinase A (MMP-2) ELISA Kit has high sensitivity and excellent specificity for detection of Human MMP2. No significant cross-reactivity or interference between Human MMP2 and analogues was observed.