Human MARVEL domain-containing protein 2 (MARVELD2) ELISA Kit

MARVELD2, or tricellulin (TRIC), is an integral membrane protein concentrated at the vertically oriented TJ strands of tricellular contacts.The 555-amino acid protein contains cytoplasmic N and C termini, 2 transmembrane domains, and 2 extracellular loops. Northern blot analysis detected high expression of Tric in epithelium-derived tissues, including small intestine, kidney, and lung. Western blot analysis of mouse epithelial cell lines revealed an approximately 66-kD protein, as well as larger phosphorylated intracellular forms. Immunofluorescence microscopy showed expression of Tric predominantly at tricellular contacts where occludin (OCLN)-positive bicellular TJs converged. Tric-positive structures appeared as short rods through confocal microscopy.

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SPECIFICATIONS

Catalog Number

KTE61721

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

153562

Accession

Q8N4S9

Additional Info

Human MARVEL domain-containing protein 2 (MARVELD2) ELISA Kit has high sensitivity and excellent specificity for detection of Human MARVELD2. No significant cross-reactivity or interference between Human MARVELD2 and analogues was observed.