Human Loricrin (LOR) ELISA Kit

Loricrin is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.\nThere were multiple sequence variants within these 2 size class alleles due to various deletions of 12 bp (4 amino acids) in the major loop of this glycine loop domain. By use of a specific loricrin antibody in immunogold electron microscopy, they showed that loricrin appears initially in the granular layer of human epidermis and forms composite keratohyalin granules with profilaggrin, but localizes to the cell periphery (cell envelope) of fully differentiated stratum corneum cells.

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SPECIFICATIONS

Catalog Number

KTE61801

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

4014

Accession

P23490

Additional Info

Human Loricrin (LOR) ELISA Kit has high sensitivity and excellent specificity for detection of Human LOR. No significant cross-reactivity or interference between Human LOR and analogues was observed.