Human Linker for activation of T cell (LAT) ELISA Kit

Linker of Activated T cells also known as LAT is a protein which is encoded by the LAT gene. Alternative splicing results in multiple transcript variants encoding different isoforms.\nThe protein encoded by this gene is phosphorylated by ZAP70/SYK protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts (also known as glycosphingolipid-enriched microdomains or GEMs) and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement.

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SPECIFICATIONS

Catalog Number

KTE61851

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

27040

Accession

O43561

Additional Info

Human Linker for activation of T cell (LAT) ELISA Kit has high sensitivity and excellent specificity for detection of Human LAT. No significant cross-reactivity or interference between Human LAT and analogues was observed.