Human Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) ELISA Kit

LAIR1 is a type I membrane protein with a leader sequence, an extracellular domain, a transmembrane domain, and a cytoplasmic region. LAIR-1 is a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.

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SPECIFICATIONS

Catalog Number

KTE61866

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

3903

Accession

Q6GTX8

Additional Info

Human Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) ELISA Kit has high sensitivity and excellent specificity for detection of Human LAIR1. No significant cross-reactivity or interference between Human LAIR1 and analogues was observed.