Human Krueppel-like factor 4 (KLF4) ELISA Kit

Krueppel-like factor 4 acts as a transcriptional activator or repressor depending on the promoter context and/or cooperation with other transcription factors. For example, Klf4 transactivates the iNOS promoter in cooperation with p65 (RelA), and the p21Cip1/Waf1 promoter in cooperation with p53, but it directly suppresses the p53 promoter and inhibits ornithine decarboxylase promoter activity by competing with specificity protein-1 (Sp-1). Klf4 also interacts with the p300/CBP transcription co-activators.KLF4 also contains a potential nuclear localization signal. The human KLF4 protein shares 91% sequence identity with mouse Ezf. Northern blot analysis detected a 3.5-kb KLF4 transcript in RNA from both human umbilical vein endothelial cells and human aortic endothelial cells.

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SPECIFICATIONS

Catalog Number

KTE61905

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

9314

Accession

O43474

Additional Info

Human Krueppel-like factor 4 (KLF4) ELISA Kit has high sensitivity and excellent specificity for detection of Human KLF4. No significant cross-reactivity or interference between Human KLF4 and analogues was observed.