Human Keratin, type I cytoskeletal 12 (KRT12) ELISA Kit

Keratin 12 is a keratin found expressed in corneal epithelia. Mutations in the gene encoding this protein lead to Meesmann corneal dystrophy. To elucidate the function of keratin 12, Kao et al. (1996) created knockout mice lacking the Krt1.12 gene by gene targeting techniques. The heterozygous mice appeared normal. Homozygous mice developed normally and suffered mild corneal epithelial erosion. The corneal epithelia were fragile and could be removed by gentle rubbing of the eyes or brushing. The corneal epithelium of the homozygotes did not express keratin 12 as judged by immunohistochemistry, Western immunoblot analysis with epitope-specific anti-keratin 12 antibodies, Northern hybridization, and in situ hybridization with an antisense keratin 12 riboprobe.

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SPECIFICATIONS

Catalog Number

KTE61886

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

3859

Accession

Q99456

Additional Info

Human Keratin, type I cytoskeletal 12 (KRT12) ELISA Kit has high sensitivity and excellent specificity for detection of Human KRT12. No significant cross-reactivity or interference between Human KRT12 and analogues was observed.