Human Kallikrein-4 (KLK4) ELISA Kit

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.\nKLK4 was predominantly expressed in nuclei of basal cells in the prostate epithelium, in keeping with its distribution in prostate cancer cells in vitro. Adenovirus-mediated KLK4 expression dramatically induced proliferation of prostate cancer cells, at least in part, through significant alterations in cell cycle regulatory gene expression. Consistent with this data, small interfering RNA-mediated knockdown of endogenous KLK4 in LNCaP prostate cancer cells inhibited cell growth.

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SPECIFICATIONS

Catalog Number

KTE61897

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

9622

Accession

Q9Y5K2

Additional Info

Human Kallikrein-4 (KLK4) ELISA Kit has high sensitivity and excellent specificity for detection of Human KLK4. No significant cross-reactivity or interference between Human KLK4 and analogues was observed.