Human Hepatocyte growth factor receptor (c-MET/HGFR) ELISA Kit

MET encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of METare also associated with multiple human cancers.

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SPECIFICATIONS

Catalog Number

KTE61644

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

4233

Accession

P08581

Additional Info

Human Hepatocyte growth factor receptor (c-MET/HGFR) ELISA Kit has high sensitivity and excellent specificity for detection of Human MET. No significant cross-reactivity or interference between Human MET and analogues was observed.