Human Egl nine homolog 1 (EGLN1) ELISA Kit

EGLN1 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. The genes encoding these proteins were cloned and termed PHD1, PHD2, and PHD3 by the authors. Direct modulation of recombinant enzyme activity by graded hypoxia, iron chelation, and cobaltous ions mirrored the characteristics of HIF induction in vivo, fulfilling requirements for these enzymes being oxygen sensors that regulate HIF.

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SPECIFICATIONS

Catalog Number

KTE61942

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

54583

Accession

Q9GZT9

Additional Info

Human Egl nine homolog 1 (EGLN1) ELISA Kit has high sensitivity and excellent specificity for detection of Human EGLN1. No significant cross-reactivity or interference between Human EGLN1 and analogues was observed.