Human EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) ELISA Kit

EGF-containing fibulin-like extracellular matrix protein 1 spans approximately 18 kb of genomic DNA and consists of 12 exons. Alternative splice patterns in the 5' UTR result in three transcript variants encoding the same extracellular matrix protein. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. The cDNA for this gene, designated 'fibrillin-like' (FBNL), was isolated from a fibroblast cDNA library. The FBNL cDNA probe detected 2 transcripts of 2.2 and 3.0 kb in mRNA from multiple tissues. The FBNL gene is expressed in many tissues but it is not expressed in brain and lymphocytes. the amino acid sequence of the FBNL gene is 36.3% identical to FBN1 and 35.4% identical to FBN2 and that FBNL contains repeated cbEGF-like domains, a cardinal motif of FBN genes.

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SPECIFICATIONS

Catalog Number

KTE61952

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

2202

Accession

Q12805

Additional Info

Human EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) ELISA Kit has high sensitivity and excellent specificity for detection of Human EFEMP1. No significant cross-reactivity or interference between Human EFEMP1 and analogues was observed.