Human Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) ELISA Kit

DYRK1A encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region.

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SPECIFICATIONS

Catalog Number

KTE62263

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

1859

Accession

Q13627

Additional Info

Human Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) ELISA Kit has high sensitivity and excellent specificity for detection of Human DYRK1A. No significant cross-reactivity or interference between Human DYRK1A and analogues was observed.