Human Dopamine D2 receptor (D2R) ELISA Kit

D2 (DRD2). There is a short version of D2 (D2Sh) and a long version of D2 (D2Lh): The D2Sh are pre-synaptic situated, having modulatory functions (called autoreceptor, they regulate the neurotransmission by feed-back mechanisms, i.e., synthesis, storage and release of dopamine into the synaptic cleft).\nThe D2Lh may have the classic function of a post-synaptic receptor, i.e., keep going on the neurotransmission (excitatory or inhibitory) once blocked by a receptor antagonist or stimulated by the endogenous neurotransmitter itself or a synthetic full or partial agonist.D2-like activation is coupled to the G protein G?i, which subsequently increases phosphodiesterase activity. Phosphodiesterases break down cAMP, producing an inhibitory effect in neurons.

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SPECIFICATIONS

Catalog Number

KTE61979

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

1813

Accession

P14416

Additional Info

Human Dopamine D2 receptor (D2R) ELISA Kit has high sensitivity and excellent specificity for detection of Human DRD2. No significant cross-reactivity or interference between Human DRD2 and analogues was observed.