Human DNA repair endonuclease XPF (ERCC4) ELISA Kit

The predicted human ERCC4 protein has 2 leucine zipper domains in the N-terminal region. ERCC4 protein expressed in mammalian cells has a molecular mass of 110-kD by Western blot analysis. In cells of an XPF patient, ERCC4 protein levels were less than 5% of normal. Nucleotide excision repair (NER), which is defective in xeroderma pigmentosum, involves incision of a DNA strand on each side of a lesion.\nThere is evidence that the 2 incisions made during NER are catalyzed by separate DNA endonucleases. In humans, XPG endonuclease makes the 3-prime incision relative to the lesion. The ERCC4 gene encodes a protein that together with ERCC1 make up the ERCC1-XPF 5-prime endonuclease

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SPECIFICATIONS

Catalog Number

KTE62261

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

2072

Accession

Q92889

Additional Info

Human DNA repair endonuclease XPF (ERCC4) ELISA Kit has high sensitivity and excellent specificity for detection of Human ERCC4. No significant cross-reactivity or interference between Human ERCC4 and analogues was observed.