Human Dihydrolipoyl Transacetylase (DLAT) ELISA Kit

Dihydrolipoyl transacetylase is the component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure.

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SPECIFICATIONS

Catalog Number

KTE62036

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

1737

Accession

P10515

Additional Info

Human Dihydrolipoyl Transacetylase (DLAT) ELISA Kit has high sensitivity and excellent specificity for detection of Human DLAT. No significant cross-reactivity or interference between Human DLAT and analogues was observed.