Human Deoxyribonuclease-1 (DNASE1) ELISA Kit

DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. It has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis.DNase I binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. The function of this interaction is unclear. However since actin-bound DNase I is enzymatically inactive, the DNase-actin complex might be a storage form of DNase I that prevents damage of the genetic information.

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SPECIFICATIONS

Catalog Number

KTE61998

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

1773

Accession

P24855

Additional Info

Human Deoxyribonuclease-1 (DNASE1) ELISA Kit has high sensitivity and excellent specificity for detection of Human DNASE1. No significant cross-reactivity or interference between Human DNASE1 and analogues was observed.