Human Deleted in malignant brain tumors 1 protein (DMBT1) ELISA Kit

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system.

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SPECIFICATIONS

Catalog Number

KTE62015

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

1755

Accession

Q9UGM3

Additional Info

Human Deleted in malignant brain tumors 1 protein (DMBT1) ELISA Kit has high sensitivity and excellent specificity for detection of Human DMBT1. No significant cross-reactivity or interference between Human DMBT1 and analogues was observed.