Human Decorin/Bone proteoglycan II (DCN) ELISA Kit

DCN encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. DCN and the related gene biglycan are thought to be the result of a gene duplication. Mutations in DCN are associated with congenital stromal corneal dystrophy in human patients.