Human Cyclin-D-binding Myb-like transcription factor 1 (DMTF1) ELISA Kit

DMTF1 encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer.

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SPECIFICATIONS

Catalog Number

KTE62006

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

9988

Accession

Q9Y222

Additional Info

Human Cyclin-D-binding Myb-like transcription factor 1 (DMTF1) ELISA Kit has high sensitivity and excellent specificity for detection of Human DMTF1. No significant cross-reactivity or interference between Human DMTF1 and analogues was observed.