Human Coagulation factor IX (F9) ELISA Kit

F9 encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of F9, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

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SPECIFICATIONS

Catalog Number

KTE61940

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

2158

Accession

P00740

Additional Info

Human Coagulation factor IX (F9) ELISA Kit has high sensitivity and excellent specificity for detection of Human F9. No significant cross-reactivity or interference between Human F9 and analogues was observed.